Dawson W, Boot J R, Harvey J, Walker J R
Eur J Rheumatol Inflamm. 1982;5(2):61-8.
Benoxaprofen has three pharmacological activities which may relate to its clinical activity profile. The most important of these for anti-inflammatory therapy is the regulation of directional monocyte movement in response to a stimulus but the inhibitory activity against lipoxygenase may be of considerable relevance in the treatment of asthma. The relatively weak inhibitory action on prostaglandin synthetase probably confers clinical benefit with a reduced potential to cause severe gastric side effects. Benoxaprofen is an inhibitor pf the lipoxygenase enzyme which converts arachidonic acid to hydroxy derivatives and the leukotrienes. These products are potent pharmacological agents with potentially important roles in inflammation and hypersensitivity disorders.
苯恶洛芬具有三种药理活性，这可能与其临床活性特征有关。其中对于抗炎治疗最重要的是对刺激作出反应时定向单核细胞运动的调节，但对脂氧合酶的抑制活性在哮喘治疗中可能具有相当重要的意义。对前列腺素合成酶相对较弱的抑制作用可能带来临床益处，同时降低引起严重胃部副作用的可能性。苯恶洛芬是一种脂氧合酶抑制剂，该酶可将花生四烯酸转化为羟基衍生物和白三烯。这些产物是强效药理剂，在炎症和超敏反应性疾病中可能发挥重要作用。
