2-氯乙醇、2-溴乙醇、1,2-环氧丁烷、环氧氯丙烷和缩水甘油醛在肺炎克雷伯菌、黑腹果蝇和L5178Y小鼠淋巴瘤细胞中的致突变性比较。

Comparison of the mutagenic potency of 2-chloroethanol, 2-bromoethanol, 1,2-epoxybutane, epichlorohydrin and glycidaldehyde in Klebsiella pneumoniae, Drosophila melanogaster and L5178Y mouse lymphoma cells.

作者信息

Knaap A G, Voogd C E, Kramers P G

出版信息

Mutat Res. 1982 May;101(3):199-208. doi: 10.1016/0165-1218(82)90153-7.

Abstract

A series of 2 haloethanols and 3 epoxides was investigated in 3 mutagenicity test systems, namely (1) the fluctuation test in Klebsiella pneumoniae, (2) the sex-linked recessive lethal test in Drosophila melanogaster, and (3) the HGPRT test with L5178Y mouse lymphoma cells. The order of mutagenic potency was, in Klebsiella: glycidaldehyde greater than 2-bromoethanol = epichlorohydrin greater than 1,2-epoxybutane greater than 2-chloroethanol; in Drosophila: glycidaldehyde = epichlorohydrin greater than 1,2-epoxybutane; in mouse lymphoma cells: epichlorohydrin greater than 1,2-epoxybutane. The haloethanols were non-mutagenic in Drosophila. 2-Chloroethanol and glycidaldehyde were negative in mouse lymphoma cells. The high mutagenic potency of epichlorohydrin as compared with 1,2-epoxybutane was consistent in all systems, and with published data.

摘要

对一系列2种卤代乙醇和3种环氧化合物在3种致突变性测试系统中进行了研究，即：（1）肺炎克雷伯菌中的波动试验；（2）黑腹果蝇中的性连锁隐性致死试验；（3）L5178Y小鼠淋巴瘤细胞的次黄嘌呤-鸟嘌呤磷酸核糖转移酶（HGPRT）试验。在肺炎克雷伯菌中，致突变活性顺序为：缩水甘油醛＞2-溴乙醇 = 环氧氯丙烷＞1,2-环氧丁烷＞2-氯乙醇；在果蝇中：缩水甘油醛 = 环氧氯丙烷＞1,2-环氧丁烷；在小鼠淋巴瘤细胞中：环氧氯丙烷＞1,2-环氧丁烷。卤代乙醇在果蝇中无致突变性。2-氯乙醇和缩水甘油醛在小鼠淋巴瘤细胞中呈阴性。与1,2-环氧丁烷相比，环氧氯丙烷的高致突变活性在所有系统中均一致，且与已发表的数据相符。