通过用去除Ia阳性细胞的供体血液进行免疫来预防同种异体移植排斥反应。
Prevention of allograft rejection by immunization with donor blood depleted of Ia-bearing cells.
作者信息
Faustman D, Lacy P, Davie J, Hauptfeld V
出版信息
Science. 1982 Jul 9;217(4555):157-8. doi: 10.1126/science.6806903.
PMID:6806903
Abstract
Strain-specific unresponsiveness was induced in adult mice by immunizing them with donor blood treated with antiserum to Ia (I region-associated antigens) prior to the transplantation of islets of Langerhans. This regimen alone produced greater than 100-day survival of islet allografts transplanted across a major histocompatibility barrier.
摘要
在成年小鼠中，通过在移植胰岛前用抗Ia（I区相关抗原）抗血清处理供体血液来诱导品系特异性无反应性。单独这种方案使跨越主要组织相容性屏障移植的胰岛同种异体移植物存活超过100天。
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