趋化因子以及影响中性粒细胞移动的介质对无氧糖酵解和己糖磷酸支路活性的作用。
The effect of chemotactic factors and agents which influence neutrophil movement on anaerobic glycolysis and hexose monophosphate shunt activity.
作者信息
Anderson R, Glover A, Rabson A R
出版信息
Immunology. 1978 Jul;35(1):141-9.
The effects of two chemotactic factors, endotoxin activated serm (EAS) and casein and a number of drugs known to affect intracellular cyclic nucleotide levels and various froms of neutrophil movement, on neutrophil anaerobic glycolysis and hexose monophosphate shunt (HMPS) activity were assessed. EAS caused stimulation of glycolysis. HMPS activity and NBT reduction, but casein was without effect on glycolysis and NBT reduction and inhibited HMPS activity. Drug known to increase intracellular cAMP levels caused a depression of HMPS activity whereas those reported to elevate cGMP had a variety of effects. Glycolysis was not affected by any of these agents. These results indicate a lack of relationship between cyclic nucleotide effect on cell motility and neutrophil glycolysis and HMPS activity.
评估了两种趋化因子（内毒素激活血清（EAS）和酪蛋白）以及一些已知会影响细胞内环核苷酸水平和中性粒细胞多种运动形式的药物对中性粒细胞无氧糖酵解和磷酸己糖旁路（HMPS）活性的影响。EAS可刺激糖酵解、HMPS活性和NBT还原，但酪蛋白对糖酵解和NBT还原无影响，且抑制HMPS活性。已知能增加细胞内cAMP水平的药物会导致HMPS活性降低，而据报道能升高cGMP的药物则有多种作用。这些药物均未影响糖酵解。这些结果表明，环核苷酸对细胞运动性的影响与中性粒细胞糖酵解和HMPS活性之间缺乏关联。
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