抗坏血酸对人中性粒细胞中磷酸己糖旁路的刺激作用：作用机制
Stimulation of the hexose monophosphate shunt in human neutrophils by ascorbic acid: mechanism of action.
作者信息
DeChatelet L R, Cooper M R, McCall C E
出版信息
Antimicrob Agents Chemother. 1972 Jan;1(1):12-6. doi: 10.1128/AAC.1.1.12.
Abstract
The addition of either ascorbic acid or dehydroascorbic acid to a suspension of polymorphonuclear leukocytes caused a dramatic increase in the resting hexose monophosphate shunt activity. A sequence of reactions involving dehydroascorbate, reduced glutathione, and reduced nicotinamide adenine dinucleotide phosphate is described to explain this stimulation. This sequence could provide an alternate method of producing H(2)O(2) and a bactericidal mechanism which is independent of myeloperoxidase.
摘要
向多形核白细胞悬液中添加抗坏血酸或脱氢抗坏血酸会导致静止状态下的己糖磷酸旁路活性急剧增加。本文描述了一系列涉及脱氢抗坏血酸盐、还原型谷胱甘肽和还原型烟酰胺腺嘌呤二核苷酸磷酸的反应，以解释这种刺激作用。该反应序列可以提供一种产生过氧化氢的替代方法以及一种独立于髓过氧化物酶的杀菌机制。
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