具有OKT4或OKT8表型的人淋巴细胞在培养中产生白细胞介素2。
Human lymphocytes with either the OKT4 or OKT8 phenotype produce interleukin 2 in culture.
作者信息
Luger T A, Smolen J S, Chused T M, Steinberg A D, Oppenheim J J
出版信息
J Clin Invest. 1982 Aug;70(2):470-3. doi: 10.1172/jci110637.
Abstract
In this study, we demonstrate that both highly purified T4+ and T8+ lymphocytes can produce substantial amounts of Interleukin 2(IL 2) when stimulated with the combination of concanavalin A (Con A) and phorbol myristate acetate. Furthermore, addition of IL 1 to macrophage-depleted T lymphocytes significantly increased IL 2 production by lymphocytes of either the T4+ or T8+ phenotype. These findings provide a basis for further studies of the molecular mechanisms involved in human immune cell interactions.
摘要
在本研究中，我们证明，当用刀豆球蛋白A（Con A）和佛波酯组合刺激时，高度纯化的T4 +和T8 +淋巴细胞均可产生大量白细胞介素2（IL 2）。此外，向去除巨噬细胞的T淋巴细胞中添加IL 1可显著增加T4 +或T8 +表型淋巴细胞的IL 2产生。这些发现为进一步研究人类免疫细胞相互作用所涉及的分子机制提供了基础。
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Human lymphocytes with either the OKT4 or OKT8 phenotype produce interleukin 2 in culture.具有OKT4或OKT8表型的人淋巴细胞在培养中产生白细胞介素2。
J Clin Invest. 1982 Aug;70(2):470-3. doi: 10.1172/jci110637.
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本文引用的文献
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The biochemistry, biology, and role of interleukin 2 in the induction of cytotoxic T cell and antibody-forming B cell responses.白细胞介素2在诱导细胞毒性T细胞和抗体形成B细胞反应中的生物化学、生物学及作用。
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Macrophage-independent activation of helper T cells. I. Production of Interleukin 2.辅助性T细胞的巨噬细胞非依赖性激活。I. 白细胞介素2的产生
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T cell requirements for generation of helper factor(s) in man: analysis of the subsets involved.人类中产生辅助因子的T细胞需求：对相关亚群的分析。
J Immunol. 1980 Apr;124(4):1883-7.
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Murine epidermal cell-derived thymocyte-activating factor resembles murine interleukin 1.小鼠表皮细胞衍生的胸腺细胞激活因子类似于小鼠白细胞介素1。
J Immunol. 1982 May;128(5):2147-52.
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Lymphokines: their role in lymphocyte responses. Properties of interleukin 1.淋巴因子：它们在淋巴细胞反应中的作用。白细胞介素1的特性。
Fed Proc. 1982 Feb;41(2):257-62.
8
Lymphocyte activating factor promotes T-cell growth factor production by cloned murine lymphoma cells.淋巴细胞激活因子可促进克隆的鼠淋巴瘤细胞产生T细胞生长因子。
Nature. 1980 Oct 30;287(5785):853-5. doi: 10.1038/287853a0.
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Responder cells in the human autologous mixed lymphocyte reaction.人类自体混合淋巴细胞反应中的反应细胞。
J Clin Invest. 1981 Dec;68(6):1601-4. doi: 10.1172/jci110416.
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