人类自体混合淋巴细胞反应中的反应细胞。
Responder cells in the human autologous mixed lymphocyte reaction.
作者信息
Smolen J S, Luger T A, Chused T M, Steinberg A D
出版信息
J Clin Invest. 1981 Dec;68(6):1601-4. doi: 10.1172/jci110416.
Abstract
Isolated human T4+ cells proliferate in the autologous mixed lymphocyte reaction (AMLR), whereas isolated T8+ cells do not. However, in the presence of Interleukin 2 or T4+ cells, the T8+ cells demonstrated substantial proliferation. These studies suggest that T8+ cells recognize signals from autologous non-T cells, but require an additional factor for the subsequent proliferative response. Since this stimulus can be provided by T4+ cells, the AMLR appears to constitute an inducer circuit. Different defects in this circuit may be responsible for the common abnormality of the AMLR in different diseases.
摘要
分离出的人T4+细胞在自体混合淋巴细胞反应（AMLR）中会增殖，而分离出的T8+细胞则不会。然而，在白细胞介素2或T4+细胞存在的情况下，T8+细胞表现出显著的增殖。这些研究表明，T8+细胞识别来自自体非T细胞的信号，但后续的增殖反应需要额外的因子。由于这种刺激可以由T4+细胞提供，AMLR似乎构成了一个诱导回路。该回路中的不同缺陷可能是导致不同疾病中AMLR常见异常的原因。
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