Solana R, Santamaría M, de la Fuente M, Peña J
Rev Esp Fisiol. 1982 Mar;38(1):1-4.
It has been recently demonstrated that macrophages are necessary accessory cells for T-lymphocyte activation by antigens, mitogens and allogenic cells. This paper shows the function of metabolically inactive macrophages in the activation of T-lymphocytes by phytohemagglutinin (PHA). Macrophages inactivated by mitomycin C are unable to collaborate with T-lymphocytes in the development of the proliferative response to PHA indicating that the role of the macrophage in T-lymphocyte activation by mitogens goes beyond insolubilizing it or rendering it more stimulatory by another passive mechanism.
最近已证实，巨噬细胞是抗原、丝裂原和同种异体细胞激活T淋巴细胞所必需的辅助细胞。本文展示了代谢不活跃的巨噬细胞在植物血凝素（PHA）激活T淋巴细胞中的作用。被丝裂霉素C灭活的巨噬细胞无法与T淋巴细胞协同作用，以产生对PHA的增殖反应，这表明巨噬细胞在丝裂原激活T淋巴细胞中的作用不仅仅是使其不溶解或以另一种被动机制使其更具刺激性。
