Miyakawa I, Inoue H, Kuroki T, Lee H C, Azegami M, Mori N
Antimicrob Agents Chemother. 1984 Jan;25(1):147-8. doi: 10.1128/AAC.25.1.147.
The concentrations of cefotiam dihydrochloride (CTM) in maternal and fetal blood and in amniotic fluid were determined by bioassay in 38 women at parturition. With an intravenous infusion of 1 g of CTM, the decline in concentration of CTM in maternal blood was biphasic; CTM was not detectable at 6 h after administration. Peak levels of CTM in umbilical cord blood (13.0 to 23.9 micrograms/ml) were attained between 15 and 28 min after intravenous infusion; those in amniotic fluid (19.6 to 23.5 micrograms/ml) were attained at ca. 2.5 h.
采用生物测定法测定了38例分娩期妇女母血、脐血和羊水中盐酸头孢替安（CTM）的浓度。静脉输注1g CTM后，母血中CTM浓度呈双相下降；给药后6小时检测不到CTM。静脉输注后15至28分钟，脐血中CTM达到峰值水平（13.0至23.9微克/毫升）；羊水中的CTM峰值水平（19.6至23.5微克/毫升）约在2.5小时达到。
