Mitchell H W
Br J Pharmacol. 1982 Dec;77(4):701-5. doi: 10.1111/j.1476-5381.1982.tb09349.x.
1 Indomethacin enhances muscle contraction to histamine in the pig isolated trachea. The effect of three cyclo-oxygenase/lipoxygenase inhibitors on these potentiated histamine-induced responses was examined. 2 At the higher concentrations BW 755c (113-226 microM), 5, 8, 11, 14-eicosatetraynoic acid (ETYA, 10-100 microM) and phenidone (5-500 microM) abolished the effect of indomethacin on tracheal contractions to histamine (100 microM). 3 Each of the three inhibitors also reduced the slope of the histamine concentration-response curve obtained in the presence of indomethacin. However, the sensitivity (pD2) of the smooth muscle to histamine was not affected by BW 755c, ETYA or phenidone. 4 The results provide further support for a lipoxygenase-dependent component of indomethacin-induced hyper-reactivity in the pig trachea.
1 吲哚美辛可增强猪离体气管对组胺的肌肉收缩反应。研究了三种环氧化酶/脂氧合酶抑制剂对这些增强的组胺诱导反应的影响。2 在较高浓度下，BW 755c（113 - 226微摩尔）、5, 8, 11, 14 - 二十碳四烯酸（ETYA，10 - 100微摩尔）和非那吡啶（5 - 500微摩尔）消除了吲哚美辛对气管对组胺（100微摩尔）收缩反应的影响。3 这三种抑制剂中的每一种还降低了在吲哚美辛存在下获得的组胺浓度 - 反应曲线的斜率。然而，平滑肌对组胺的敏感性（pD2）不受BW 755c、ETYA或非那吡啶的影响。4 这些结果为吲哚美辛诱导的猪气管高反应性中依赖脂氧合酶的成分提供了进一步的支持。
