Lyberg T, Prydz H
Eur J Clin Invest. 1982 Jun;12(3):229-34. doi: 10.1111/j.1365-2362.1982.tb00997.x.
Immune complexes induced the synthesis of apoprotein III, the protein component of tissue thromboplastin (tissue factor), in human monocytes cultured in vitro. The response was maximal (11.1 +/- 1.7 fold increase (mean +/- SEM) when immune complexes were formed at antigen/antibody equivalence. Immune complexes formed with the antigen-binding fragments (F(ab')2) of immunoglobulins induced a 4.7 +/- 1.4 fold activity increase, suggesting that another signal mechanism in addition to the Fc-receptor may be involved.
免疫复合物可诱导体外培养的人单核细胞合成载脂蛋白III，即组织凝血活酶（组织因子）的蛋白质成分。当免疫复合物在抗原/抗体等价时形成，反应最为强烈（平均增加11.1±1.7倍（平均值±标准误））。用免疫球蛋白的抗原结合片段（F(ab')2）形成的免疫复合物可使活性增加4.7±1.4倍，这表明除Fc受体外可能还涉及另一种信号机制。
