Lyberg T, Prydz H, Baklien K, Høyeraal H M
Thromb Res. 1982 Feb 1;25(3):193-202. doi: 10.1016/0049-3848(82)90238-9.
Monocytes isolated from peripheral blood of patients with various rheumatic diseases and circulating immune complexes (IC) developed a significantly higher thromboplastin (tissue factor) activity than normal cells when cultured in vitro without inducers, but normal cells responded more strongly with thromboplastin production upon stimulation with IC or phytohaemagglutinin (PHA). Sera from patients with rheumatic diseases and circulating IC induced a significant increase in the thromboplastin activity of normal monocytes. Lysozyme release from patient monocytes was significantly lower than the release from control cells when stimulated with IC. Patient sera contained higher amounts of lysozyme than normal sera, indicating lysozyme release in vivo. These data suggest that activation of monocytes in vivo by IC may take place. The increased expression of thromboplastin in monocytes/tissue macrophages may be important for the development of microvascular thrombosis and fibrin deposition seen in chronic inflammatory lesions.
从患有各种风湿性疾病的患者外周血中分离出的单核细胞以及循环免疫复合物（IC），在无诱导剂的体外培养时，其凝血活酶（组织因子）活性显著高于正常细胞，但正常细胞在受到IC或植物血凝素（PHA）刺激时，凝血活酶产生反应更为强烈。患有风湿性疾病且有循环IC的患者血清可使正常单核细胞的凝血活酶活性显著增加。当受到IC刺激时，患者单核细胞的溶菌酶释放量显著低于对照细胞。患者血清中的溶菌酶含量高于正常血清，表明体内有溶菌酶释放。这些数据提示，IC可能在体内激活单核细胞。单核细胞/组织巨噬细胞中凝血活酶表达的增加可能对慢性炎症病变中所见的微血管血栓形成和纤维蛋白沉积的发展具有重要意义。
