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十八个仓鼠×绵羊成纤维细胞杂交系中绵羊组织相容性基因OLA - A1、A8、B7、B9和OLX - 5分离情况的比较

Comparison of the segregation of sheep histocompatibility genes OLA - A1, A8, B7, B9, and OLX-5 in eighteen hamster X sheep fibroblast hybrid lines.

作者信息

Millot P

出版信息

J Immunogenet. 1982 Jun;9(3):185-9. doi: 10.1111/j.1744-313x.1982.tb00790.x.

DOI:10.1111/j.1744-313x.1982.tb00790.x
PMID:6809838
Abstract

Four OLA factors of the ovine histocompatibility complex and the OLX -5 factor were recognized in hamster cell X sheep fibroblast hybrids, by means of absorption of OLA reagents with hybrid cells. Segregation of these factors could be studied in eighteen independent hybrids. In the case described, the four OLA factors were distributed into two haplotypes isolated in some hybrids. The heterozygous OLX-5 factor was linked to only one haplotype; nevertheless a dissociation, occurred in one hybrid (relative to five simultaneous transmissions), is in agreement with a previous genetic study showing a loose linkage between the OLA complex and the OLX locus.

摘要

通过用杂交细胞吸收OLA试剂,在仓鼠细胞X绵羊成纤维细胞杂种中识别出绵羊组织相容性复合体的四个OLA因子和OLX -5因子。这些因子的分离可在18个独立的杂种中进行研究。在所描述的案例中,四个OLA因子分布在一些杂种中分离出的两个单倍型中。杂合的OLX-5因子仅与一个单倍型连锁;然而,在一个杂种中发生了分离(相对于五个同时传递),这与先前的遗传研究一致,该研究表明OLA复合体和OLX位点之间存在松散的连锁关系。

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