Naim M, Rogatka H, Yamamoto T, Zehavi U
Physiol Behav. 1982 Jun;28(6):979-86. doi: 10.1016/0031-9384(82)90163-9.
Preference-aversion behavior to solutions containing neohesperidin dihydrochalcone (NHDHC) was studied rats and baboon monkeys. Electrophysiological responses evoked by application of NHDHC solutions to taste receptors innervated by the chorda tympani and the glossopharyngeal nerves were also measured. As a group, rats were indifferent to solutions containing up to 1.2 x 10(-3) M NHDHC in short and long-term preference tests. A solution containing the very high concentration of 8.2 x 10(-3) M NHDHC was consumed less than water by all rats. The aversive behavior of rats to the 8.2 x 10(-3) M NHDHC solution appeared to be due to taste quality rather than olfaction. When percent preferences were calculated on an individual basis for the long-term preference tests, 59% of the rats were indifferent to solutions containing up to 1.2 x 10(-3) M NHDHC, 33% of the animals found this solution aversive and less than 8% showed preference. Behavioral responses to a solution of 3.4 x 10(-4) M aspartame also varied considerably among rats. The electrophysiological data were in line with the behavioral responses suggesting weak taste responses for NHDHC in rats. More pronounced responses observed in the glossopharyngeal nerve as compared to the chorda tympani. Baboon monkeys showed a strong preference for solutions containing 1.6 x 10(-5) M-1.6 x 10(-3) M NHDHC. A solution of 1.6 x 10(-2) M was consumed to a lesser extent than water. It is concluded that baboon monkeys present a better experimental model than rats for investigating the sweetness of NHDHC.
对含有新橙皮苷二氢查耳酮（NHDHC）的溶液的偏好 - 厌恶行为在大鼠和狒狒中进行了研究。还测量了将NHDHC溶液应用于由鼓索神经和舌咽神经支配的味觉感受器所诱发的电生理反应。作为一个群体，在短期和长期偏好测试中，大鼠对含有高达1.2×10⁻³ M NHDHC的溶液无明显偏好。所有大鼠对含有非常高浓度8.2×10⁻³ M NHDHC的溶液的消耗量均低于水。大鼠对8.2×10⁻³ M NHDHC溶液的厌恶行为似乎是由于味觉性质而非嗅觉。在长期偏好测试中以个体为基础计算偏好百分比时，59%的大鼠对含有高达1.2×10⁻³ M NHDHC的溶液无明显偏好，33%的动物觉得该溶液令人厌恶，不到8%的动物表现出偏好。大鼠对3.4×10⁻⁴ M阿斯巴甜溶液的行为反应也有很大差异。电生理数据与行为反应一致，表明大鼠对NHDHC的味觉反应较弱。与鼓索神经相比，在舌咽神经中观察到更明显的反应。狒狒对含有1.6×10⁻⁵ M - 1.6×10⁻³ M NHDHC的溶液表现出强烈偏好。1.6×10⁻² M的溶液消耗量低于水。得出的结论是，在研究NHDHC的甜度方面，狒狒比大鼠是更好的实验模型。
