Tammisto T, Aromaa U
Acta Anaesthesiol Scand. 1982 Jun;26(3):225-30. doi: 10.1111/j.1399-6576.1982.tb01759.x.
The aim of the study was to quantitate the degree of respiratory depression when tolerance of superficial nociception and of an endotracheal tube was achieved by supplementing N2O + O2 anaesthesia either with halothane alone or with halothane in combination with fentanyl. Eighty-four patients, matched into seven groups, were studied after induction of anaesthesia with thiopental (4 mg/kg) and suxamethonium (3 mg/kg) using the following supplementation: 0.8, 0.6, 0.4% halothane alone or 0.4, 0.2, 0% halothane with 0.5-2 micrograms/kg fentanyl. After 10 min administration of the anaesthetic mixture using manual intermittent positive pressure ventilation (IPPV) (end-tidal CO2 c. 5.5%), IPPV was discontinued and spontaneous respiration allowed to return. When the end-tidal CO2 had stabilized, samples for blood gas analysis were taken and superficial antinociception was tested by pinching an inguinal skin fold. Supplementation of an N2O + O2 mixture with 0.8% halothane without fentanyl or with 0.4% halothane with 0.5 microgram/kg fentanyl seemed to come closest to the optimum in producing tolerance of an endotracheal tube and of superficial nociception (in about 85% of cases with an increase in PCO2 to only 7 kPa.
本研究的目的是，在通过单独使用氟烷或氟烷与芬太尼联合使用来补充N2O + O2麻醉，从而实现对浅部伤害感受和气管内导管的耐受性时，定量呼吸抑制的程度。84例患者被分为7组，在使用硫喷妥钠（4 mg/kg）和琥珀酰胆碱（3 mg/kg）诱导麻醉后，采用以下补充剂进行研究：单独使用0.8%、0.6%、0.4%氟烷，或0.4%、0.2%、0%氟烷与0.5 - 2微克/千克芬太尼。在使用手动间歇性正压通气（IPPV）（呼气末CO2约5.5%）给予麻醉混合剂10分钟后，停止IPPV并让自主呼吸恢复。当呼气末CO2稳定后，采集血样进行血气分析，并通过捏腹股沟皮肤皱襞来测试浅部抗伤害感受。用0.8%氟烷且无芬太尼或0.4%氟烷与0.5微克/千克芬太尼补充N2O + O2混合剂，似乎最接近产生气管内导管耐受性和浅部伤害感受耐受性的最佳状态（在约85%的病例中，PCO2仅升高至7 kPa）。
