Svoboda V, Sedlák A, Bubeníková D, Klener V
Czech Med. 1982;5(2):80-9.
Some results of long-term experiments performed in mice contaminated with 226Ra and 239Pu, especially the damage to the hemopoietic system and the incidence of osteosarcoma, are reported. Different degree of damage to the bone marrow hemopoiesis, depending on the arrangement of marrow cavities and the capability of stem cells to produce differentiated progeny are evaluated. This ability decreases with age and with duration of the contamination due to radionuclides. From the above aspects of radiation injury the ability of hemopoiesis to compensate the decreased production of differentiated peripheral cell forms is discussed. It is remarkable that myeloid leukemia occurred earlier and more frequently in 239Pu-contaminated animals than in controls. After the injection of plutonium-239, myeloid and lymphatic leukemias were diagnosed in most of the animals dying without osteosarcoma. These diseases represented a danger not lower than that of osteosarcoma which appeared in average later and the expected incidence of which was estimated to rise linearly with age. The findings are discussed from the aspect of their application in evaluating the risk resulting for man from the incorporated bone-seeking alpha emitters.
报告了在受226镭和239钚污染的小鼠身上进行的长期实验的一些结果，特别是对造血系统的损害和骨肉瘤的发生率。根据骨髓腔的排列以及干细胞产生分化后代的能力，评估了对骨髓造血的不同程度损害。由于放射性核素，这种能力会随着年龄和污染持续时间而下降。从辐射损伤的上述方面讨论了造血补偿分化外周细胞形式产量下降的能力。值得注意的是，与对照组相比，239钚污染的动物中髓系白血病发生得更早且更频繁。注射239钚后，大多数未患骨肉瘤而死亡的动物被诊断出患有髓系和淋巴系白血病。这些疾病的危险性不低于骨肉瘤，骨肉瘤平均出现较晚，预计其发病率会随年龄呈线性上升。从这些研究结果在评估人体因摄入亲骨性α发射体而产生的风险中的应用方面进行了讨论。
