Svoboda V, Bubeníková D
Institute of Hygiene and Epidemiology, Center of Radiation Hygiene, Radiotoxicology, Prague, Czechoslovakia.
Neoplasma. 1990;37(6):639-46.
Female ICR mice were injected intravenously with low activities of 239Pu (3.0 kBq, 6.0 kBq, 12.3 kBq/kg). In these mice with high spontaneous incidence of hemoblastoses the occurrence of myeloid leukemia, lymphocytic leukemia, lymphosarcoma, reticulum-cell sarcomas and osteosarcoma was studied. Hemoblastoses, on the whole, remained in their numbers radiation-independent, nevertheless, the distribution into specific types changed, with moderate prevalence of myeloid and lymphocytic leukemia and lymphosarcoma. After plutonium injection the mean survival time of mice bearing myeloid and lymphocytic neoplasias was significantly shorter than the survival of mice that died of retothelosarcoma and from other causes. These contamination-dependent differences could not be observed in matched controls. As expected, 239Pu activities used in this experiment induced osteosarcomas. Whereas in leukemogenesis alpha-radiation appeared as a factor promoting and modifying the leukemogenic process, in osteosarcoma the alpha-particles acted rather as an initiator, the effect of which was dependent on the dose to the endosteal progenitor cells.
将低活度的239Pu（3.0 kBq、6.0 kBq、12.3 kBq/kg）静脉注射给雌性ICR小鼠。在这些造血系统疾病自发发生率较高的小鼠中，研究了髓性白血病、淋巴细胞白血病、淋巴肉瘤、网状细胞肉瘤和骨肉瘤的发生情况。总体而言，造血系统疾病的数量与辐射无关，不过，其在特定类型中的分布发生了变化，髓性和淋巴细胞白血病以及淋巴肉瘤的发生率中等。注射钚后，患有髓性和淋巴细胞肿瘤的小鼠的平均存活时间明显短于死于网状内皮肉瘤和其他原因的小鼠的存活时间。在匹配的对照组中未观察到这些与污染相关的差异。正如预期的那样，本实验中使用的239Pu活度诱发了骨肉瘤。在白血病发生过程中，α辐射似乎是促进和改变白血病发生过程的一个因素，而在骨肉瘤中，α粒子更像是引发剂，其作用取决于对骨内膜祖细胞的剂量。
