Svoboda V, Klener V, Bubeníková D, Kotasková Z
Neoplasma. 1980;27(5):567-74.
Terminal hematological changes were studied in female ICR mice injected intravenously with 181.1 kBq/kg of monomeric 239Pu. Cellularity and differential cell counts in femoral bone marrow and spleen, as well as peripheral blood counts were determined. The results were evaluated with respect to the quantitative hematological changes and to the diagnosis of proliferative disorders. As far as the nonstochastic response is concerned, evidently decreased cell counts, without abnormalities in myelogram, were observed in the femoral bone marrow of 239Pu-treated mice and only a mild leukopenia was present in peripheral blood. No significant difference was observed between the hematological response of tumor-bearing mice and the response of mice free of osteosarcomas.
对静脉注射181.1 kBq/kg单体239Pu的雌性ICR小鼠的终末血液学变化进行了研究。测定了股骨骨髓和脾脏中的细胞数量及细胞分类计数，以及外周血细胞计数。根据血液学的定量变化和增殖性疾病的诊断对结果进行了评估。就非随机反应而言，在接受239Pu治疗的小鼠的股骨骨髓中观察到细胞计数明显减少，而骨髓象无异常，外周血中仅出现轻度白细胞减少。荷瘤小鼠的血液学反应与无骨肉瘤小鼠的反应之间未观察到显著差异。
