日本人群中MB系统与哮喘之间的关联。

Association between the MB system and asthma in the Japanese.

作者信息

Nakai Y, Kano T, Moriuchi J, Wakisaka A, Aizawa M, Tsuneta H, Togashi K, Sakiyama Y, Wagatsuma Y, Matsumoto S

出版信息

Hum Immunol. 1982 Jun;4(3):265-70. doi: 10.1016/0198-8859(82)90042-8.

Abstract

Twenty-three unrelated Japanese patients with asthma who showed a high total serum IgE level, a strong skin test response to Dermatophagoides farinae, and a high score on a radioallergosorbent test (RAST) using Dermatophagoides farinae were typed for HLA-A locus, -B locus, and -D region antigens. No significant difference in the frequencies of HLA-A, -B, and -DR antigens were observed between the asthma patients and the healthy controls. A significant difference in the frequency of MB3', however, was found between the asthma patients and the healthy controls (corrected p = 0.04, relative risk = 18.5).

摘要

对23名患有哮喘的非亲属日本患者进行了HLA - A位点、 - B位点和 - D区域抗原分型，这些患者血清总IgE水平较高，对粉尘螨皮肤试验反应强烈，且使用粉尘螨进行的放射变应原吸附试验（RAST）得分较高。哮喘患者与健康对照之间在HLA - A、 - B和 - DR抗原频率上未观察到显著差异。然而，哮喘患者与健康对照之间在MB3'频率上存在显著差异（校正p = 0.04，相对风险 = 18.5）。