Bradley M O, Patterson S, Zwelling L A
Mutat Res. 1982 Sep;96(1):67-74. doi: 10.1016/0027-5107(82)90017-3.
This work shows that cis-diaminedichloroplatinum(II)'s (cis-DDP) mutagenicity, as well as its cytotoxicity, can be prevented by subsequent treatment with thiourea. Sister-chromatid exchanges (SCE) induced by cis-DDP are only partially prevented by thiourea under conditions where mutagenicity is totally inhibited. A 4.5-h delay in the addition of thiourea following cis-DDP treatment results in an almost complete loss of its ability to prevent mutagenicity, but only a partial loss of its ability to prevent cytotoxicity and sister-chromatid exchanges.
这项研究表明，顺二氯二氨铂（II）（顺铂）的致突变性及其细胞毒性可通过随后用硫脲处理来预防。在致突变性被完全抑制的条件下，硫脲只能部分预防顺铂诱导的姐妹染色单体交换（SCE）。顺铂处理后延迟4.5小时添加硫脲，其预防致突变性的能力几乎完全丧失，但预防细胞毒性和姐妹染色单体交换的能力仅部分丧失。
