Gautier H, Gaudy J H
J Appl Physiol Respir Environ Exerc Physiol. 1978 Aug;45(2):171-6. doi: 10.1152/jappl.1978.45.2.171.
The tidal volume-inspiratory duration relationship was studied during air breathing and rebreathing in conscious and anesthetized human subjects using three different intravenous agents. The results observed have been compared with similar experiments carried out in cats. Its has been shown that anesthesia provokes an increase in breathing rate associated with a decrease in tidal volume in human subjects; an opposite effect on breathing rate was observed in cats. Thus, the tidal volume-inspiratory duration relationship, although very similar in the conscious cat or human subject, is very different under anesthesia. The results were quite consistent in a given species whatever the nature of the drug used. It is suggested that modifications of the breathing rate by anesthesia, related to animal species, are caused by central effects of the drug. These effects are probably mediated by different actions on inputs to the inspiratory "off-switch" mechanisms in the two species.
在清醒和麻醉的人体受试者中，使用三种不同的静脉药物，研究了空气呼吸和重复呼吸过程中潮气量与吸气持续时间的关系。将观察到的结果与在猫身上进行的类似实验进行了比较。结果表明，麻醉会导致人体受试者呼吸频率增加，同时潮气量减少；而在猫身上观察到的是对呼吸频率的相反影响。因此，潮气量与吸气持续时间的关系，尽管在清醒的猫或人体受试者中非常相似，但在麻醉状态下却非常不同。无论使用何种药物，在给定物种中结果都相当一致。有人认为，麻醉对呼吸频率的改变与动物物种有关，是由药物的中枢作用引起的。这些作用可能是通过对两种物种吸气“关闭开关”机制的输入产生不同作用来介导的。
