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黑腹果蝇修复-重组缺陷突变体中核糖体DNA扩增现象的研究。

A study of rDNA magnification phenomenon in a repair-recombination deficient mutant of Drosophila melanogaster.

作者信息

Polito L C, Cavaliere D, Zazo A, Furia M

出版信息

Genetics. 1982 Sep;102(1):39-48. doi: 10.1093/genetics/102.1.39.

DOI:10.1093/genetics/102.1.39
PMID:6813189
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1201923/
Abstract

The rDNA magnification process consists of a rapid and inheritable rDNA increase occurring in bobbed males: in a few generations the bb loci acquire the wild-type rDNA value and reach a bb+ phenotype.--We have analyzed the rDNA magnification process in the repair-recombination-deficient mutant mei9a, both at the phenotypical and rDNA content levels. In mei9a bb double mutants the recovery of bb+ phenotype is strongly disturbed and the rDNA redundancy value fails to reach the wild-type level. The strong effect of this meiotic mutation on rDNA magnification suggests a close relationship between this phenomenon and the repair-recombination processes.

摘要

rDNA 扩增过程包括在截毛雄蝇中发生的快速且可遗传的 rDNA 增加：在几代之内，bb 位点获得野生型 rDNA 值并达到 bb+表型。——我们已经在表型和 rDNA 含量水平上分析了修复 - 重组缺陷型突变体 mei9a 中的 rDNA 扩增过程。在 mei9a bb 双突变体中，bb+表型的恢复受到强烈干扰，并且 rDNA 冗余值未能达到野生型水平。这种减数分裂突变对 rDNA 扩增的强烈影响表明该现象与修复 - 重组过程之间存在密切关系。

相似文献

1
A study of rDNA magnification phenomenon in a repair-recombination deficient mutant of Drosophila melanogaster.黑腹果蝇修复-重组缺陷突变体中核糖体DNA扩增现象的研究。
Genetics. 1982 Sep;102(1):39-48. doi: 10.1093/genetics/102.1.39.
2
Comparison between rDNA magnification and bb lethal mutation frequencies in Drosophila melanogaster.黑腹果蝇中核糖体DNA扩增与bb致死突变频率的比较。
Mol Gen Genet. 1980;180(3):511-5. doi: 10.1007/BF00268054.
3
Repair-defect mutations inhibit rDNA magnification in Drosophila and discriminate between meiotic and premeiotic magnification.修复缺陷突变抑制果蝇中的核糖体DNA扩增，并区分减数分裂和减数分裂前的扩增。
Proc Natl Acad Sci U S A. 1985 Dec;82(23):8095-9. doi: 10.1073/pnas.82.23.8095.
4
Patterns of reversion to bobbed condition of magnified bobbed loci in D. melanogaster.黑腹果蝇中放大的截毛位点回复到截毛状态的模式。
Mol Gen Genet. 1979 Oct 2;176(1):81-5. doi: 10.1007/BF00334298.
5
Autosomal modifiers of the bobbed phenotype are a major component of the rDNA magnification paradox in Drosophila melanogaster.截毛表型的常染色体修饰因子是黑腹果蝇核糖体DNA扩增悖论的主要组成部分。
Genetics. 1986 Jun;113(2):305-19. doi: 10.1093/genetics/113.2.305.
6
The effect of mei-41 on rDNA redundancy in Drosophila melanogaster.mei-41对黑腹果蝇核糖体DNA冗余的影响。
Genetics. 1983 May;104(1):63-80. doi: 10.1093/genetics/104.1.63.
7
Unequal mitotic sister chromatin exchange as the mechanism of ribosomal RNA gene magnification.不均等有丝分裂姐妹染色质交换作为核糖体RNA基因扩增的机制。
Proc Natl Acad Sci U S A. 1974 Apr;71(4):1272-6. doi: 10.1073/pnas.71.4.1272.
8
rDNA magnification in D. melanogaster: state of rDNA copies following the first step.黑腹果蝇中的核糖体DNA扩增：第一步之后核糖体DNA拷贝的状态
Mol Gen Genet. 1979 Jan 2;167(3):271-7. doi: 10.1007/BF00267419.
9
Instability at the bobbed locus following magnification in Drosophila melanogaster.黑腹果蝇放大后截毛位点的不稳定性
Mol Gen Genet. 1976 Feb 2;143(3):261-8. doi: 10.1007/BF00269402.
10
Regulation of rRNA gene number in Drosophila melanogaster: new aspects resulting from the use of free duplications.黑腹果蝇中核糖体RNA基因数量的调控：使用游离重复序列产生的新方面。
Mol Gen Genet. 1984;194(3):485-8. doi: 10.1007/BF00425562.

引用本文的文献

1
Differential magnification of rDNA gene types in bobbed mutants of Drosophila melanogaster.黑腹果蝇截毛突变体中rDNA基因类型的差异放大
Mol Gen Genet. 1987 Jun;208(1-2):168-76. doi: 10.1007/BF00330438.
2
Autosomal modifiers of the bobbed phenotype are a major component of the rDNA magnification paradox in Drosophila melanogaster.截毛表型的常染色体修饰因子是黑腹果蝇核糖体DNA扩增悖论的主要组成部分。
Genetics. 1986 Jun;113(2):305-19. doi: 10.1093/genetics/113.2.305.

本文引用的文献

1
Exchanges at the bobbed locus of Drosophila melanogaster.黑腹果蝇截毛位点的交换。
Genetics. 1969 Sep;63(1):133-53. doi: 10.1093/genetics/63.1.133.
2
Genetic analysis of sex chromosomal meiotic mutants in Drosophilia melanogaster.黑腹果蝇性染色体减数分裂突变体的遗传分析。
Genetics. 1972 Jun;71(2):255-86. doi: 10.1093/genetics/71.2.255.
3
rDNA magnification at the bobbed locus of the Y chromosome in Drosophila melanogaster.黑腹果蝇Y染色体的截毛位点处的核糖体DNA扩增
Cell Differ. 1972 Jun;1(2):133-42. doi: 10.1016/0045-6039(72)90036-x.
4
Crossing-over between X AND Y chromosomes during ribosomal DNA magnification in Drosophila melanogaster.黑腹果蝇核糖体DNA扩增过程中X与Y染色体之间的交换。
Proc Natl Acad Sci U S A. 1973 Jul;70(7):1950-4. doi: 10.1073/pnas.70.7.1950.
5
The mei-9 alpha mutant of Drosophila melanogaster increases mutagen sensitivity and decreases excision repair.黑腹果蝇的mei-9α突变体增加了诱变敏感性并降低了切除修复能力。
Genetics. 1976 Nov;84(3):527-44. doi: 10.1093/genetics/84.3.527.
6
Genetic controls of meiotic recombination and somatic DNA metabolism in Drosophila melanogaster.黑腹果蝇减数分裂重组和体细胞DNA代谢的遗传控制
Proc Natl Acad Sci U S A. 1976 Nov;73(11):4140-4. doi: 10.1073/pnas.73.11.4140.
7
Increase of rDNA redundancy in bb females of Drosophila melanogaster.黑腹果蝇bb雌性中核糖体DNA冗余度的增加。
Mol Gen Genet. 1976 Jun 15;145(3):255-8. doi: 10.1007/BF00325821.
8
Patterns of reversion to bobbed condition of magnified bobbed loci in D. melanogaster.黑腹果蝇中放大的截毛位点回复到截毛状态的模式。
Mol Gen Genet. 1979 Oct 2;176(1):81-5. doi: 10.1007/BF00334298.