黑腹果蝇修复-重组缺陷突变体中核糖体DNA扩增现象的研究。

A study of rDNA magnification phenomenon in a repair-recombination deficient mutant of Drosophila melanogaster.

作者信息

Polito L C, Cavaliere D, Zazo A, Furia M

出版信息

Genetics. 1982 Sep;102(1):39-48. doi: 10.1093/genetics/102.1.39.

DOI:10.1093/genetics/102.1.39

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1201923/

Abstract

The rDNA magnification process consists of a rapid and inheritable rDNA increase occurring in bobbed males: in a few generations the bb loci acquire the wild-type rDNA value and reach a bb+ phenotype.--We have analyzed the rDNA magnification process in the repair-recombination-deficient mutant mei9a, both at the phenotypical and rDNA content levels. In mei9a bb double mutants the recovery of bb+ phenotype is strongly disturbed and the rDNA redundancy value fails to reach the wild-type level. The strong effect of this meiotic mutation on rDNA magnification suggests a close relationship between this phenomenon and the repair-recombination processes.

摘要

rDNA 扩增过程包括在截毛雄蝇中发生的快速且可遗传的 rDNA 增加：在几代之内，bb 位点获得野生型 rDNA 值并达到 bb+表型。——我们已经在表型和 rDNA 含量水平上分析了修复 - 重组缺陷型突变体 mei9a 中的 rDNA 扩增过程。在 mei9a bb 双突变体中，bb+表型的恢复受到强烈干扰，并且 rDNA 冗余值未能达到野生型水平。这种减数分裂突变对 rDNA 扩增的强烈影响表明该现象与修复 - 重组过程之间存在密切关系。

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本文引用的文献

1

Exchanges at the bobbed locus of Drosophila melanogaster.

Genetics. 1969 Sep;63(1):133-53. doi: 10.1093/genetics/63.1.133.

2

Genetic analysis of sex chromosomal meiotic mutants in Drosophilia melanogaster.

Genetics. 1972 Jun;71(2):255-86. doi: 10.1093/genetics/71.2.255.

3

rDNA magnification at the bobbed locus of the Y chromosome in Drosophila melanogaster.

Cell Differ. 1972 Jun;1(2):133-42. doi: 10.1016/0045-6039(72)90036-x.

4

Crossing-over between X AND Y chromosomes during ribosomal DNA magnification in Drosophila melanogaster.

Proc Natl Acad Sci U S A. 1973 Jul;70(7):1950-4. doi: 10.1073/pnas.70.7.1950.

5

The mei-9 alpha mutant of Drosophila melanogaster increases mutagen sensitivity and decreases excision repair.

Genetics. 1976 Nov;84(3):527-44. doi: 10.1093/genetics/84.3.527.

6

Genetic controls of meiotic recombination and somatic DNA metabolism in Drosophila melanogaster.

Proc Natl Acad Sci U S A. 1976 Nov;73(11):4140-4. doi: 10.1073/pnas.73.11.4140.

7

Increase of rDNA redundancy in bb females of Drosophila melanogaster.

Mol Gen Genet. 1976 Jun 15;145(3):255-8. doi: 10.1007/BF00325821.

8

Patterns of reversion to bobbed condition of magnified bobbed loci in D. melanogaster.

Mol Gen Genet. 1979 Oct 2;176(1):81-5. doi: 10.1007/BF00334298.

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