Gargano S, Graziani F
Mol Gen Genet. 1976 Jun 15;145(3):255-8. doi: 10.1007/BF00325821.
The purpose of this work was to analyze the difference between males and females with respect to rDNA magnification. To study eventual rDNA variations in females aYbb chromosome was chosen since it can magnify in males but not show phenomena of rDNA dosage compensation. The authors have observed an increase of rDNA pertaining to the Ybb chromosome in females of XXNO-/Ybb genotype with respect to the same Ybb chromosome studied in XXbb+/Ybb females. This non-inheritable rDNA increase cannot be explained in terms of compensatory increase reported in X/O males nor can it fit in the magnification scheme. The possibility might be entertained that some mechanism is missing in females which cannot complete a magnification cycle. The rDNA increase that we called rDNA magnification in males occurs in the germ line and in the soma, whereas the evidence, here reported, suggest that magnification in females occurs only in the soma.
这项工作的目的是分析男性和女性在核糖体DNA（rDNA）扩增方面的差异。为了研究女性中可能存在的rDNA变异，选择了aYbb染色体，因为它在男性中可以扩增，但不会出现rDNA剂量补偿现象。作者观察到，与XXbb+/Ybb雌性中研究的相同Ybb染色体相比，XXNO-/Ybb基因型雌性中与Ybb染色体相关的rDNA有所增加。这种非遗传性的rDNA增加既不能用X/O雄性中报道的补偿性增加来解释，也不符合扩增模式。有可能是女性中缺少某种机制，无法完成扩增循环。我们所说的男性中的rDNA扩增现象，其rDNA增加发生在生殖系和体细胞中，而此处报道的证据表明，女性中的扩增仅发生在体细胞中。
