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Substrate specificity and structure-activity relationships of gentamicin acetyltransferase I. The dependence of antibiotic resistance upon substrate Vmax/Km values.

作者信息

Williams J W, Northrop D B

出版信息

J Biol Chem. 1978 Sep 10;253(17):5908-14.

PMID:681328
Abstract
摘要

相似文献

1
Substrate specificity and structure-activity relationships of gentamicin acetyltransferase I. The dependence of antibiotic resistance upon substrate Vmax/Km values.庆大霉素乙酰转移酶I的底物特异性及构效关系。抗生素抗性对底物Vmax/Km值的依赖性。
J Biol Chem. 1978 Sep 10;253(17):5908-14.
2
Substrate specificities and structure-activity relationships for acylation of antibiotics catalyzed by kanamycin acetyltransferase.卡那霉素乙酰转移酶催化抗生素酰化反应的底物特异性及构效关系
Biochemistry. 1984 Oct 23;23(22):5118-22. doi: 10.1021/bi00317a006.
3
Kinetic mechanisms of gentamicin acetyltransferase I. Antibiotic-dependent shift from rapid to nonrapid equilibrium random mechanisms.
J Biol Chem. 1978 Sep 10;253(17):5902-7.
4
pH modulation of aminoglycoside resistance in Staphylococcus epidermidis harbouring 6'-N-aminoglycoside acetyltransferase.携带6'-N-氨基糖苷乙酰转移酶的表皮葡萄球菌中氨基糖苷耐药性的pH调节
J Antimicrob Chemother. 1996 May;37(5):881-9. doi: 10.1093/jac/37.5.881.
5
Purification and properties of gentamicin acetyltransferase I.庆大霉素乙酰转移酶I的纯化及性质
Biochemistry. 1976 Jan 13;15(1):125-31. doi: 10.1021/bi00646a019.
6
Aminoglycoside resistance in bacteria medicated by gentamicin acetyltransferase II, an enzyme modifying the 2'-amino group of aminoglycoside antibiotics.由庆大霉素乙酰转移酶II介导的细菌对氨基糖苷类抗生素的耐药性，该酶可修饰氨基糖苷类抗生素的2'-氨基基团。
Biochemistry. 1974 Jan 29;13(3):598-603. doi: 10.1021/bi00700a030.
7
Structure and functions of the GNAT superfamily of acetyltransferases.乙酰转移酶GNAT超家族的结构与功能
Arch Biochem Biophys. 2005 Jan 1;433(1):212-26. doi: 10.1016/j.abb.2004.09.003.
8
Gentamycin resistance in Nicotiana conferred by AAC(3)-I, a narrow substrate specificity acetyltransferase.
Plant Mol Biol. 1991 Aug;17(2):301-3. doi: 10.1007/BF00039510.
9
Thermodynamics of an aminoglycoside modifying enzyme with low substrate promiscuity: The aminoglycoside N3 acetyltransferase-VIa.底物选择性低的氨基糖苷修饰酶的热力学：氨基糖苷N3乙酰基转移酶-VIa
Proteins. 2017 Jul;85(7):1258-1265. doi: 10.1002/prot.25286. Epub 2017 Mar 29.
10
Biosynthesis of platelet activating factor. Substrate specificity of 1-alkyl-2-lyso-sn-glycero-3-phosphocholine:acetyl-CoA acetyltransferase in rat spleen microsomes.血小板活化因子的生物合成。大鼠脾脏微粒体中1-烷基-2-溶血-sn-甘油-3-磷酸胆碱：乙酰辅酶A乙酰转移酶的底物特异性。
J Biol Chem. 1985 Sep 15;260(20):10952-5.

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The role of adjuvants in overcoming antibacterial resistance due to enzymatic drug modification.佐剂在克服因酶促药物修饰导致的抗菌耐药性方面的作用。
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Small-Molecule Acetylation by GCN5-Related -Acetyltransferases in Bacteria.细菌中 GCN5 相关乙酰转移酶的小分子乙酰化作用。
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Bacterial GCN5-Related N-Acetyltransferases: From Resistance to Regulation.
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Tyrosine hydroxylase and regulation of dopamine synthesis.酪氨酸羟化酶与多巴胺合成的调控。
Arch Biochem Biophys. 2011 Apr 1;508(1):1-12. doi: 10.1016/j.abb.2010.12.017. Epub 2010 Dec 19.
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The kinetic mechanism of AAC3-IV aminoglycoside acetyltransferase from Escherichia coli.来自大肠杆菌的AAC3-IV氨基糖苷乙酰转移酶的动力学机制。
Biochemistry. 2005 Dec 13;44(49):16275-83. doi: 10.1021/bi051777d.
6
Aminoglycoside resistance resulting from tight drug binding to an altered aminoglycoside acetyltransferase.由于药物与改变的氨基糖苷类乙酰转移酶紧密结合而导致的氨基糖苷类耐药性。
Antimicrob Agents Chemother. 2003 May;47(5):1577-83. doi: 10.1128/AAC.47.5.1577-1583.2003.
7
Correlation of antibiotic resistance with Vmax/Km ratio of enzymatic modification of aminoglycosides by kanamycin acetyltransferase.抗生素耐药性与卡那霉素乙酰转移酶对氨基糖苷类进行酶促修饰的Vmax/Km比值之间的相关性。
Antimicrob Agents Chemother. 1984 Apr;25(4):479-82. doi: 10.1128/AAC.25.4.479.
8
On the evolution of Tn21-like multiresistance transposons: sequence analysis of the gene (aacC1) for gentamicin acetyltransferase-3-I(AAC(3)-I), another member of the Tn21-based expression cassette.关于Tn21样多抗性转座子的进化：基于Tn21的表达盒的另一个成员——庆大霉素乙酰转移酶-3-I（AAC(3)-I）基因（aacC1）的序列分析
Mol Gen Genet. 1989 Jun;217(2-3):202-8. doi: 10.1007/BF02464882.
9
Spectrophotometric assay for amikacin using purified kanamycin acetyltransferase.使用纯化的卡那霉素乙酰转移酶对阿米卡星进行分光光度测定。
Antimicrob Agents Chemother. 1979 Aug;16(2):221-4. doi: 10.1128/AAC.16.2.221.