Ison C, Glynn A A, Bascomb S
J Clin Pathol. 1982 Oct;35(10):1153-7. doi: 10.1136/jcp.35.10.1153.
It is suggested that part of the increased pharyngeal carriage of meningococci reported in patients with gonorrhoea is due to misidentification of gonococci which have been transformed to maltose fermenters by DNA from normal throat flora. The distribution of specific aminopeptidases in strains of gonococci, meningococci isolated from the throat and meningococci from systemic infections is consistent with this view. Gonococci oxidising maltose and gonococci with gamma-L-glutamyl aminopeptidase activity, both factors regarded as typical of Neisseria meningitidis, can be produced in vitro by transformation with DNA from N lactamica and N meningitidis. The clinical and theoretical implications of such changes are discussed.
有人认为，淋病患者中报告的脑膜炎球菌咽部携带率增加的部分原因是淋球菌被正常咽喉菌群的DNA转化为麦芽糖发酵菌后被错误鉴定。淋球菌、从咽喉分离出的脑膜炎球菌以及全身性感染的脑膜炎球菌菌株中特定氨肽酶的分布与这一观点一致。氧化麦芽糖的淋球菌和具有γ-L-谷氨酰氨肽酶活性的淋球菌，这两个因素都被视为脑膜炎奈瑟菌的典型特征，可以通过用乳酸奈瑟菌和脑膜炎奈瑟菌的DNA进行转化在体外产生。文中讨论了这些变化的临床和理论意义。
