脱嘌呤嘧啶位点与脱嘌呤嘧啶内切酶
AP sites and AP endonucleases.
作者信息
Grossman L, Grafstrom R
出版信息
Biochimie. 1982 Aug-Sep;64(8-9):577-80. doi: 10.1016/s0300-9084(82)80090-4.
PMID:6814504
Abstract
The sensitivity of internal and terminal apurinic/apyrimidinic (AP) sites to alkaline hydrolysis and beta-elimination is described. The symmetric and asymmetric modes of endonucleolytic hydrolysis by specific AP endonucleases are compared and the discrimination between their non-enzymatic and catalytic mechanism is discussed.
摘要
描述了内部和末端无嘌呤/无嘧啶（AP）位点对碱水解和β-消除的敏感性。比较了特定AP内切核酸酶进行内切核酸水解的对称和不对称模式，并讨论了它们非酶促机制和催化机制之间的区别。
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