[可拉明对大鼠肝细胞质网电子传递链酶活性的影响]

[Effect of cordiamine on the enzyme activity of the electron-transport chains of the rat liver cytoplasmic network].

作者信息

Bushma M I, Lukienko P I

出版信息

Farmakol Toksikol. 1982 Sep-Oct;45(5):80-3.

Abstract

Injection of cordiamine (diethylamide of nicotinic acid) into rats subcutaneously in doses of 40 and 120 mg/kg for 4 days led to an increase in the activity of NADPH-oxidase, NADPH-cytochrome-c- and nitrotetrasolium reductases, as well as to an elevation of cytochrome P450 content in the liver cytoplasmic network. As regards the pattern of enzyme induction, cordiamine is classified with inductors of the phenobarbital type. However, as to the activation potency, it is noticeably inferior to phenobarbital. Electron-transport function of the enzymes of the NADH-dependent redox-chain of the organella does not show essential changes after cordiamine injection.

摘要

以40毫克/千克和120毫克/千克的剂量给大鼠皮下注射可拉明（烟酸二乙胺），持续4天，导致肝脏细胞质网络中NADPH氧化酶、NADPH - 细胞色素c还原酶和硝基四氮唑还原酶的活性增加，以及细胞色素P450含量升高。就酶诱导模式而言，可拉明属于苯巴比妥类型的诱导剂。然而，就激活效力而言，它明显低于苯巴比妥。注射可拉明后，细胞器中依赖NADH的氧化还原链酶的电子传递功能未显示出明显变化。

相似文献

1

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Farmakol Toksikol. 1982 Sep-Oct;45(5):80-3.

2

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