吉尔vocarcins，新型抗肿瘤抗生素。4. 作用方式。

Gilvocarcins, new antitumor antibiotics. 4. Mode of action.

作者信息

Tomita F, Takahashi K, Tamaoki T

出版信息

J Antibiot (Tokyo). 1982 Aug;35(8):1038-41. doi: 10.7164/antibiotics.35.1038.

DOI:10.7164/antibiotics.35.1038

Abstract

The mode of action of gilvocarcins was studied. Gilvocarcins V, M and A possessed antibacterial activities decreasing in that order. Gilvocarcin V inhibited DNA synthesis in Bacillus subtilis through strong interaction with DNA and resulting cleavage. Gilvocarcin M showed interaction with DNA and a small change in DNA mobility upon electrophoresis in agarose gel, while gilvocarcin A showed no interaction with DNA, thus reflecting their relative biological activities.

摘要

对吉尔vocarcins的作用方式进行了研究。吉尔vocarcins V、M和A具有抗菌活性，其活性依次降低。吉尔vocarcin V通过与DNA的强烈相互作用并导致其裂解来抑制枯草芽孢杆菌中的DNA合成。吉尔vocarcin M显示出与DNA的相互作用，并且在琼脂糖凝胶电泳时DNA迁移率有微小变化，而吉尔vocarcin A未显示出与DNA的相互作用，从而反映了它们相对的生物学活性。