分娩早期人胎膜特定甘油磷脂中花生四烯酸的动员。

Mobilization of arachidonic acid from specific glycerophospholipids of human fetal membranes during early labor.

作者信息

Okita J R, MacDonald P C, Johnston J M

出版信息

J Biol Chem. 1982 Dec 10;257(23):14029-34.

Abstract

Arachidonic acid is mobilized from the fetal membranes (amnion and chorion laeve) during human parturition. To define the lipid species that serve as the source of arachidonic acid, we determined the lipid composition of fetal membranes obtained before and during early labor. The arachidonic acid content of diacyl phosphatidylethanolamine decreased by 41% in amnion and 20% in chorion laeve during early labor. The arachidonic acid content of phosphatidylinositol decreased by 35% in amnion and 16% in chorion laeve. No statistically significant changes were found in the arachidonic acid content of the other lipid fractions of either amnion or chorion laeve. Thus, during early labor, there is a net release of arachidonic acid specifically from diacyl phosphatidylethanolamine and phosphatidylinositol of amnion and chorion laeve. The specific decrease in the arachidonic acid content of the diacyl phosphatidylethanolamine and phosphatidylinositol of human fetal membranes during early labor, as found in the present investigation, can be accounted for by enzymatic activities that are relatively specific for the release of arachidonic acid from these two glycerophospholipids.

摘要

在人类分娩过程中，花生四烯酸从胎膜（羊膜和平滑绒毛膜）中被动员出来。为了确定作为花生四烯酸来源的脂质种类，我们测定了分娩早期之前和期间获得的胎膜的脂质组成。在分娩早期，羊膜中双酰基磷脂酰乙醇胺的花生四烯酸含量下降了41%，平滑绒毛膜中下降了20%。磷脂酰肌醇的花生四烯酸含量在羊膜中下降了35%，在平滑绒毛膜中下降了16%。在羊膜或平滑绒毛膜的其他脂质组分的花生四烯酸含量中未发现统计学上的显著变化。因此，在分娩早期，花生四烯酸有净释放，特别是从羊膜和平滑绒毛膜的双酰基磷脂酰乙醇胺和磷脂酰肌醇中释放。如本研究所发现的，在分娩早期人类胎膜的双酰基磷脂酰乙醇胺和磷脂酰肌醇的花生四烯酸含量的特定下降，可以由相对特异性地从这两种甘油磷脂中释放花生四烯酸的酶活性来解释。