Moon H W, Schwartz A, Welch M J, McCann P P, Runnels P L
Vet Pathol. 1982 Nov;19(6):700-7. doi: 10.1177/030098588201900615.
Fecal material collected from an immunologically deficient man with persistent cryptosporidia infection was stored in potassium dichromate for two weeks and then fed (inoculated) to newborn pigs. The six inoculated newborn pigs shed the organism in their feces starting four to five days afer inoculation and continuing for as long as 22 days after inoculation. Pigs which were killed and necropsied while shedding had cryptosporidia infection of ileum, cecum, and colon. Infected pigs had atrophied ileal villi and flattened irregular cecal and colonic epithelium. Uninoculated littermate controls remained free to the infection and had histologically normal intestinal tracts at necropsy. Treatment of three of the six inoculated pigs with the ornithine decarboxylase inhibitor, DL-alpha-difluoromethylornithine, orally for ten days had no apparent effect on the infection.
从一名患有持续性隐孢子虫感染的免疫缺陷男子收集的粪便样本，在重铬酸钾中储存两周后，喂给（接种给）新生仔猪。六只接种的新生仔猪在接种后四到五天开始在粪便中排出该生物体，并在接种后持续长达22天。在排虫时被宰杀并进行尸检的猪，其回肠、盲肠和结肠有隐孢子虫感染。受感染的猪回肠绒毛萎缩，盲肠和结肠上皮扁平且不规则。未接种的同窝对照仔猪未感染，尸检时肠道组织学正常。对六只接种猪中的三只口服鸟氨酸脱羧酶抑制剂DL-α-二氟甲基鸟氨酸十天，对感染没有明显影响。
