Naciri M, Mancassola R, Yvoré P, Peeters J E
I.N.R.A. Station de Pathologie Aviaire et de Parasitologie, Nouzilly, France.
Vet Parasitol. 1993 Jan;45(3-4):199-207. doi: 10.1016/0304-4017(93)90075-x.
The chemoprophylactic effects of halofuginone lactate were tested against calf experimental cryptosporidiosis. Twenty 2-day-old calves, divided into four groups, were orally inoculated with 1 x 10(6) oocysts of Cryptosporidium parvum. The infected control group was unmedicated whereas the three other groups were medicated with the drug at 30, 60 and 120 micrograms kg-1 day-1, respectively, for 7 days, from Day (D) 2 to D8 post-inoculation (D 0 was inoculation day). The calves were weighed twice weekly and disease development and drug efficacy were assessed daily from D0 to D30 from consistency of feces, shedding of oocysts and mortality. Experimental C. parvum infection caused a severe clinical disease with profuse watery diarrhea, high oocyst shedding and mortality (3 out of 5) in the unmedicated group. The results clearly demonstrated the efficacy of halofuginone lactate in reducing the severity of clinical cryptosporidiosis. This efficacy was dose-dependent. The lowest dose (30 micrograms kg-1 day-1) was not able to prevent clinical disease and mortality (3 out of 5). No clinical signs were observed with the 60 and 120 micrograms kg-1 day-1 doses, but the animals shed oocysts after drug withdrawal. This shedding was more delayed the higher the dose of drug administered, but the delayed shedding had no effect on the growth of the animals.
对乳酸盐常山酮预防犊牛实验性隐孢子虫病的效果进行了测试。20头2日龄犊牛被分为四组，口服接种1×10(6)个微小隐孢子虫卵囊。感染对照组未用药，而其他三组分别在接种后第2天（D0为接种日）至第8天，以30、60和120微克/千克体重·天的剂量用药7天。每周对犊牛称重两次，从D0至D30每天根据粪便的稠度、卵囊排出情况和死亡率评估疾病发展和药物疗效。实验性微小隐孢子虫感染导致未用药组出现严重临床疾病，伴有大量水样腹泻、高卵囊排出率和死亡率（5头中有3头死亡）。结果清楚地证明了乳酸盐常山酮在减轻临床隐孢子虫病严重程度方面的疗效。这种疗效是剂量依赖性的。最低剂量（30微克/千克体重·天）未能预防临床疾病和死亡（5头中有3头死亡）。60和120微克/千克体重·天的剂量未观察到临床症状，但动物在停药后排出卵囊。给药剂量越高，卵囊排出延迟越久，但延迟排出对动物生长没有影响。
