Borkenstein M H, Muntean W E
Diabetes. 1982 Nov;31(11):1006-9. doi: 10.2337/diacare.31.11.1006.
Factor VIII coagulant activity (VIII C) and factor VIII-related antigen (VIII R:Ag) were studied in 86 insulin-dependent diabetic children. All children were without signs of vascular disease based on a negative funduscopy, negative fluorescein angiography, normal serum creatinine levels, and absence of proteinuria. Age ranged from 4 to 17 yr; duration of clinical diabetes ranged from 1 to 12 yr. The children were grouped according to their urinary sugar excretion, the HbA1 levels, and the duration of clinical diabetes. The group with high urinary sugar excretion and the group with high HbA1 levels had a significantly higher VIII C than the group with low urinary sugar excretion and the group with low HbA1 levels. VIII C levels did not differ significantly in the groups with a different duration of clinical diabetes, but VIII R:Ag was significantly higher in the group with the longest duration of diabetes as compared with the group with the shortest duration. VIII R:Ag levels did not differ significantly in the groups with different degrees of urinary sugar excretion or different HbA1 levels. The results show that in children without vascular disease, and even in children with a short duration of diabetes, alterations of the factor VIII complex can be demonstrated.
对86名胰岛素依赖型糖尿病儿童进行了凝血因子VIII促凝活性（VIII C）和凝血因子VIII相关抗原（VIII R:Ag）的研究。所有儿童根据眼底检查阴性、荧光素血管造影阴性、血清肌酐水平正常以及无蛋白尿，均无血管疾病迹象。年龄范围为4至17岁；临床糖尿病病程范围为1至12年。根据尿糖排泄量、糖化血红蛋白（HbA1）水平以及临床糖尿病病程对儿童进行分组。尿糖排泄量高的组和HbA1水平高的组的VIII C显著高于尿糖排泄量低的组和HbA1水平低的组。临床糖尿病病程不同的组之间VIII C水平无显著差异，但糖尿病病程最长的组的VIII R:Ag显著高于病程最短的组。不同尿糖排泄程度或不同HbA1水平的组之间VIII R:Ag水平无显著差异。结果表明，在无血管疾病的儿童中，甚至在糖尿病病程短的儿童中，均可证明凝血因子VIII复合物存在改变。
