Fish W R, Looker D L, Marr J J, Berens R L
Biochim Biophys Acta. 1982 Nov 24;719(2):223-31. doi: 10.1016/0304-4165(82)90092-7.
Bloodstream forms of Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense are incapable of de novo purine synthesis. Purine bases are converted directly to ribonucleotides and with the exception of guanine, are stable. Guanine is incorporated directly into ribonucleotides and also deaminated to xanthine. Purine ribonucleosides are hydrolyzed rapidly; these reactions may limit their incorporation since purine bases label the nucleotide pools more efficiently than do ribonucleosides. The apparent order of salvage efficiency for ribonucleosides is adenosine greater than inosine greater than guanosine greater than xanthosine for both organisms. T. b. gambiense salvages purine bases in the same order, while T. b. rhodesiense salvages purine bases in the order hypoxanthine greater than adenine greater than guanine greater than xanthine.
布氏冈比亚锥虫和布氏罗得西亚锥虫的血流形式无法进行嘌呤的从头合成。嘌呤碱直接转化为核糖核苷酸，除鸟嘌呤外，都是稳定的。鸟嘌呤直接掺入核糖核苷酸，也脱氨生成黄嘌呤。嘌呤核糖核苷迅速水解；这些反应可能会限制它们的掺入，因为嘌呤碱比核糖核苷更有效地标记核苷酸池。两种锥虫中，核糖核苷的补救效率明显顺序为腺苷大于肌苷大于鸟苷大于黄苷。布氏冈比亚锥虫以相同顺序补救嘌呤碱，而布氏罗得西亚锥虫以次黄嘌呤大于腺嘌呤大于鸟嘌呤大于黄嘌呤的顺序补救嘌呤碱。
