Nath N, Fang C T, Ledman R, Mazzur S, Dodd R Y
J Infect Dis. 1978 Aug;138(2):252-6. doi: 10.1093/infdis/138.2.252.
A total of 3,212 samples of blood from asymptomatic volunteer donors positive for hepatitis B surface antigen (HBsAg) by radioimmunoassay and 860 samples negative for HBsAg were tested for the presence of hepatitis e antigen (HBeAg) and its corresponding antibody (anti-HBe) using a rheophoresis technique. Neither HBeAg nor anti-HBe was detected in any sample negative for HBsAg. Of the HBsAg-positive samples, 237 (7.4%) contained HBeAg and 749 (23.3%) had anti-HBe. HBeAg was significantly (P less than or equal to 0.0005) more likely to be in samples with high titers of HBsAg. Anti-HBe had an equal chance of occurring in samples with low or high titers of HBsAg. Both HBeAg and anti-HBe were found in samples with HBsAg subtypes ad or ay. However, a significant association (P less than or equal to 0.0005) between HBsAg/ay and HBeAg as well as an association between anti-HBe and HBsAg/ad was found.
采用对流免疫电泳技术，对3212份通过放射免疫分析检测乙型肝炎表面抗原（HBsAg）呈阳性的无症状自愿献血者的血样以及860份HBsAg呈阴性的血样进行了戊型肝炎抗原（HBeAg）及其相应抗体（抗-HBe）检测。在任何HBsAg呈阴性的样本中均未检测到HBeAg和抗-HBe。在HBsAg呈阳性的样本中，237份（7.4%）含有HBeAg，749份（23.3%）有抗-HBe。HBeAg在HBsAg高滴度的样本中出现的可能性显著更高（P小于或等于0.0005）。抗-HBe在HBsAg低滴度或高滴度的样本中出现的几率相同。在HBsAg亚型为ad或ay的样本中均发现了HBeAg和抗-HBe。然而，发现HBsAg/ay与HBeAg之间存在显著关联（P小于或等于0.0005），抗-HBe与HBsAg/ad之间也存在关联。
