1,2,3-Triazole derivatives of aryloxyalanoic acids.

Several 1,2,3-triazolederivatives of aryloxyalcanoic acids of general formula (II) were synthesized. Some derivatives were obtained by the cycloaddition reaction of 4-azidophenoxyacetic acid (III) to activated methylene compounds, but the largest part were prepared by nucleophilic substitution reactions of three new (4-hydroxyphenyl)triazole derivatives and alyphatic bromoesters. Some compounds, tested as prostaglandin-synthetase inhibitors of rat spleen in vitro, showed practically no activity; moderate activities as herbicides, insecticides and antimicrobials were detected.