蛋白质-能量营养不良对大鼠体内氯喹吸收、分布及消除的影响。

The effect of protein-energy malnutrition on the absorption, distribution and elimination of chloroquine in the rat.

Adelusi S A, Salako L A

Gen Pharmacol. 1982;13(6):505-9. doi: 10.1016/0306-3623(82)90025-8.

Abstract

Protein-energy malnutrition was induced in young rats by feeding them a protein-deficient diet. 2. The kinetics of uptake and elimination of chloroquine in various tissues were compared in normal rats, malnourished rats, and malnourished rats after recovery from malnutrition. 3. In the blood, liver, spleen, heart, kidney and skeletal muscle, uptake of chloroquine was slower in malnourished than in normal rats. Chloroquine was also eliminated at a slower rate in malnourished rats. In the skin chloroquine was taken up to a greater extent in malnourished than in normal rats. 4. When malnourished rats were allowed to recover from their state of malnutrition, the uptake and elimination of chloroquine no longer differed from those of animals that had never been malnourished.

摘要

通过给幼鼠喂食蛋白质缺乏的饮食来诱导其蛋白质能量营养不良。2. 比较了正常大鼠、营养不良大鼠以及营养不良恢复后的大鼠体内氯喹在各种组织中的摄取和消除动力学。3. 在血液、肝脏、脾脏、心脏、肾脏和骨骼肌中，营养不良大鼠对氯喹的摄取比正常大鼠慢。氯喹在营养不良大鼠中的消除速度也较慢。在皮肤中，营养不良大鼠比正常大鼠摄取更多的氯喹。4. 当营养不良的大鼠从营养不良状态恢复后，氯喹的摄取和消除与从未营养不良的动物不再有差异。