Fried W, Barone S J, Anagnostou A
J Lab Clin Med. 1978 Aug;92(2):303-10.
Experiments were performed to determined the effect of protein deprivation on CFU-S in the spleen and femoral marrow, on the peripheral blood counts, and on the rate at which these parameters regenerate following radiation. Splenic CFU-S decrease in number after only 3 days on diets containing 5% protein or less. Marrow CFU-S, on the other hand, decrease only after mice are fed a protein-free diet for 4 weeks or more. The hematocrits, platelet counts, and WBC counts fall in the latter group. Marrow CFU-S regenerate more slowly in irradiated mice fed diets containing 5% protein or less. Also, the hemocrits, WBC counts, and platelet counts of irradiated mice fed diets containing 5% protein regenerate more slowly than do those of irradiated mice fed normal diets. The effect of protein deprivation on erythropoietin production, erythropoiesis, granulocyte function, and immunocompetence is well known. The studies reported here indicate, in addition, that protein deprivation also causes the numbers of CFU-S and the platelet counts to decline.
开展实验以确定蛋白质缺乏对脾脏和股骨骨髓中脾集落形成单位（CFU-S）、外周血细胞计数以及这些参数在辐射后再生速率的影响。在含5%或更少蛋白质的饮食喂养仅3天后，脾脏CFU-S数量就会减少。另一方面，只有在小鼠食用无蛋白饮食4周或更长时间后，骨髓CFU-S数量才会减少。后一组的血细胞比容、血小板计数和白细胞计数会下降。在食用含5%或更少蛋白质饮食的受辐照小鼠中，骨髓CFU-S再生更慢。此外，食用含5%蛋白质饮食的受辐照小鼠的血细胞比容、白细胞计数和血小板计数的再生速度比食用正常饮食的受辐照小鼠更慢。蛋白质缺乏对促红细胞生成素产生、红细胞生成、粒细胞功能和免疫能力的影响是众所周知的。此处报告的研究还表明，蛋白质缺乏还会导致CFU-S数量和血小板计数下降。
