生物功能发生改变的突变单克隆抗体。
Mutant monoclonal antibodies with alterations in biological functions.
作者信息
Yelton D E, Scharff M D
出版信息
J Exp Med. 1982 Oct 1;156(4):1131-48. doi: 10.1084/jem.156.4.1131.
Abstract
Somatic cell mutants with deletions in the immunoglobulin constant region were isolated from an IgG(2b) Ar-binding hybridoma. Rat anti-mouse immunoglobulins were used to identify the sites of the deletions. The mutant monoclonal antibodies differ from the parental molecule in their assembly states and are defective in various immunoglobulin activities, making them potentially more useful reagents.
摘要
从一株IgG(2b) 抗Ar结合杂交瘤中分离出免疫球蛋白恒定区有缺失的体细胞突变体。用大鼠抗小鼠免疫球蛋白来鉴定缺失位点。突变的单克隆抗体在组装状态上与亲本分子不同，并且在各种免疫球蛋白活性方面存在缺陷，这使得它们有可能成为更有用的试剂。
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