Freeman R, McPeake P K
Thorax. 1982 Oct;37(10):732-6. doi: 10.1136/thx.37.10.732.
The isolation rate and spread of infection and colonisation with Pseudomonas aeruginosa in a cardiothoracic intensive care unit was studied over two and a half years. The overall acquisition rate was low (2.68%) and was concentrated in the group of patients undergoing prolonged intensive care (over seven days). Although some cross-infection from long-stay to short-stay patients occurred in 1978 and 1979, when cubicle isolation was inadequate, acquisition of Ps aeruginosa was confined to the long-stay group when isolation facilities became sufficient. Further study of the long-stay patients disclosed two factors--use of broad-spectrum antibiotics and tracheostomy--significantly associated with acquisition of Ps aeruginosa. The possible uses of the results obtained and the particular relevance of a policy of narrow-spectrum chemoprophylaxis for open-heart surgery are discussed.
在两年半的时间里，对一家心胸重症监护病房中铜绿假单胞菌的感染分离率以及感染和定植的传播情况进行了研究。总体获得率较低（2.68%），且集中在接受长时间重症监护（超过七天）的患者群体中。尽管在1978年和1979年，当病房隔离措施不足时，发生了一些从长期住院患者到短期住院患者的交叉感染，但当隔离设施变得充足时，铜绿假单胞菌的获得仅限于长期住院患者群体。对长期住院患者的进一步研究揭示了两个因素——使用广谱抗生素和气管切开术——与铜绿假单胞菌的获得显著相关。讨论了所获结果的可能用途以及窄谱化学预防策略对心脏直视手术的特殊相关性。
