Holloway A M, Jordaan D G, Brock-Utne J G
Anaesth Intensive Care. 1982 Nov;10(4):340-3. doi: 10.1177/0310057X8201000408.
Midazolam was compared with thiopentone as an intravenous anaesthetic induction agent in children between four and twelve years of age undergoing elective minor surgical procedures. Successful induction of anaesthesia was achieved in both groups of patients. With midazolam induction time was longer than with thiopentone, but the difference was not statistically significant. The incidence of apnoea was greater with thiopentone, but not significantly so. It is concluded that midazolam is effective and safe, and could prove a reasonable alternative to thiopentone as an intravenous induction agent in children undergoing elective minor operations.
在4至12岁接受择期小手术的儿童中，将咪达唑仑与硫喷妥钠作为静脉麻醉诱导剂进行了比较。两组患者均成功诱导麻醉。使用咪达唑仑时诱导时间比使用硫喷妥钠时长，但差异无统计学意义。硫喷妥钠引起呼吸暂停的发生率更高，但差异也不显著。结论是，咪达唑仑有效且安全，在接受择期小手术的儿童中，可证明是硫喷妥钠作为静脉诱导剂的合理替代药物。
