Fehrmann P, Schmidt S, Fehrmann P L, Sulzmann R, Zühlke H
Anat Anz. 1982;152(2):159-69.
From the findings of our investigations can be concluded that after long-lasting in vivo gifts of glibenclamid and glucose a decrease of the glucose-induced secretion of insulin in the B-cells of the islets of Langerhans is resulting. After strong experimental stimulation during the existence of an abnormal metabolic situation the synthesis of insulin had not been disturbed and there were also no clear signs of exhaustion of the activity in the islets. Probably, biosynthesis of insulin is coming off only more quickly and is inducing a reduction of insulin already in the cell itself (according to the increased occurrence of lysosomes). The changed production of insulin which can be detected biochemically is, in some conditions, resulting from a temporally disturbance of the mechanism of secretion in the B-cells.
从我们的调查结果可以得出结论，在长期体内给予格列本脲和葡萄糖后，朗格汉斯胰岛β细胞中葡萄糖诱导的胰岛素分泌会减少。在异常代谢状况存在期间进行强烈实验刺激后，胰岛素的合成未受干扰，胰岛中也没有明显的活性耗尽迹象。可能胰岛素的生物合成只是进行得更快，并在细胞自身内就导致胰岛素减少（根据溶酶体出现增加）。在某些情况下，通过生化检测到的胰岛素产生变化是由于β细胞分泌机制的暂时紊乱所致。
