Gastaut H, Iemolo F
Ital J Neurol Sci. 1982 Oct;3(3):193-6. doi: 10.1007/BF02043308.
7 cases of stuporous states or coma induced in epileptic subjects by the rapid administration of high doses of sodium valproate are described. Progressive impairment of consciousness began 2 to 7 days after the administration of sodium valproate and induced a slowing of background EEG activity until the delta activity became of high amplitude, generalized, continuous and areactive. The authors believe that the impairment of consciousness in their patients was related to the rapid administration of high doses and a direct intrinsic action of sodium valproate on the brain, as no increase in plasma levels of the drugs in association with valproate was observed.
本文描述了7例癫痫患者因快速大剂量服用丙戊酸钠而导致的木僵状态或昏迷。意识进行性障碍在服用丙戊酸钠后2至7天开始出现，并导致脑电图背景活动减慢，直至出现高波幅、广泛性、持续性且无反应性的δ波活动。作者认为，其患者的意识障碍与快速大剂量用药以及丙戊酸钠对大脑的直接内在作用有关，因为未观察到与丙戊酸相关的药物血浆水平升高。
