BW755C 在体外增强淋巴细胞活化。
Enhancement of lymphocyte activation by BW755C in vitro.
作者信息
Ali A T, Morley J
出版信息
Agents Actions. 1982 Dec;12(5-6):645-9. doi: 10.1007/BF01965073.
PMID:6819771
Abstract
BW755C considerably enhances the increased DNA synthesis of lymphocytes responding to mitogen stimulation. This effect is evident at much lower concentrations of BW755C than are required to inhibit cyclooxygenase or lipoxygenase enzymes. This suggests that in vivo effects of BW755C may not solely depend upon modification of arachidonic acid metabolism.
摘要
BW755C显著增强了对有丝分裂原刺激作出反应的淋巴细胞中增加的DNA合成。在比抑制环氧化酶或脂氧化酶所需浓度低得多的BW755C浓度下，这种作用就很明显。这表明BW755C的体内作用可能不仅仅取决于花生四烯酸代谢的改变。
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