Parkinson J R, Evarts C M, Hubbard L F
Hip. 1982:211-27.
The administration of radiation to prevent heterotopic bone formation after total hip arthroplasty has been highly successful in this prospective study. It was extremely effective in high-risk patients, including those with preexisting heterotopic ossification. No early deleterious effects were noted. Long-term follow-up is planned to observe for late tumor induction. No wound complications were encountered. Trochanteric nonunions did occur and may be in part related to the radiation. This study demonstrated the importance of the early initiation of treatment. Ninety-eight percent of high-risk patients who began treatment on the second to fourth day postoperatively were free of heterotopic bone after surgery. Meticulous technique is always employed to eliminate debris in the surgical wound, and soft tissues are handled carefully. The search continues for a more complete explanation of the pathogenesis of heterotopic bone formation. A current study has been constructed to demonstrate the minimum dose of radiation that will continue to be effective. Further evaluation of methods to more accurately identify the high-risk patient continues. The effectiveness of radiation therapy in the prevention of heterotopic bone following total hip replacement has been shown.
在这项前瞻性研究中，采用放射疗法预防全髋关节置换术后异位骨形成取得了巨大成功。对于高危患者，包括那些已有异位骨化的患者，该方法极其有效。未观察到早期有害影响。计划进行长期随访以观察是否有晚期肿瘤诱发情况。未出现伤口并发症。确实发生了转子不愈合，这可能部分与放射治疗有关。本研究证明了早期开始治疗的重要性。术后第二至四天开始治疗的高危患者中，98%术后无异位骨形成。始终采用精细的技术清除手术伤口中的碎屑，并小心处理软组织。人们仍在继续探寻对异位骨形成发病机制更全面的解释。目前已开展一项研究，以证明持续有效的最小放射剂量。对更准确识别高危患者方法的进一步评估仍在继续。放射治疗在预防全髋关节置换术后异位骨形成方面的有效性已得到证实。
