Trau H, Rigel D S, Harris M N, Kopf A W, Friedman R J, Gumport S L, Bart R S, Grier W R
Cancer. 1983 Feb 1;51(3):553-6. doi: 10.1002/1097-0142(19830201)51:3<553::aid-cncr2820510332>3.0.co;2-t.
Although thin malignant melanomas, i.e., those less than 0.76 mm in thickness, of the skin generally do not metastasize, it has been recently reported that when histologic regression is present, such lesions may then have a greater propensity for dissemination. However, this was not apparent in this study in which only one melanoma metastasized in a consecutive series of 41 thin lesions which were step-sectioned and had evidence of regression histologically. Possible explanations for this discrepancy are the failure of other authors to include only step-sectioned specimens of the primary melanomas in their material and/or geographic differences in the biologic behavior of this malignant neoplasm.
尽管皮肤薄的恶性黑色素瘤，即厚度小于0.76毫米的那些，通常不会发生转移，但最近有报道称，当存在组织学消退时，此类病变可能更易于扩散。然而，在本研究中这并不明显，在该研究中，在连续的41个经连续切片且组织学上有消退证据的薄病变中，只有一例黑色素瘤发生了转移。这种差异的可能解释是，其他作者在其材料中未仅纳入原发性黑色素瘤的连续切片标本，和/或该恶性肿瘤生物学行为存在地理差异。
