Crum C P, Egawa K, Barron B, Fenoglio C M, Levine R U, Richart R M
Gynecol Oncol. 1983 Feb;15(1):88-94. doi: 10.1016/0090-8258(83)90120-8.
Two hundred fifty consecutive cases previously diagnosed as advanced intraepithelial neoplasia (CIN 2 and CIN III) were reviewed and examined for the presence of coexisting condyloma. When the mean ages and age distributions were analyzed, there was a consistent shift of the age distribution to a younger age among women with CIN and condyloma as opposed to CIN alone. Furthermore, when the relationship between age and case accumulation was normalized from a curvilinear to a linear relationship, there were significant differences in the slope of the accumulation rate between cohorts of CIN III with and without condyloma. These differences suggest that the concordant observation of both lesions in a given patient is not a random process resulting from two independent events but rather indicates an underlying dependence between the two (i.e., condyloma and CIN). It cannot, however, be determined statistically whether the associated condyloma is directly responsible for the CIN lesion or hastens its transit time.
对250例先前被诊断为高级别上皮内瘤变（CIN 2和CIN III）的连续病例进行回顾，并检查是否存在并存的尖锐湿疣。分析平均年龄和年龄分布时，与单纯CIN患者相比，患有CIN和尖锐湿疣的女性年龄分布一致地向更年轻的年龄段偏移。此外，当年龄与病例累积之间的关系从曲线关系归一化为线性关系时，伴有和不伴有尖锐湿疣的CIN III队列之间累积率的斜率存在显著差异。这些差异表明，在特定患者中同时观察到这两种病变并非两个独立事件导致的随机过程，而是表明两者（即尖锐湿疣和CIN）之间存在潜在的相关性。然而，无法从统计学上确定相关的尖锐湿疣是否直接导致CIN病变或加速其发展进程。
