Boon M E, Fox C H
Acta Cytol. 1981 Jul-Aug;25(4):393-9.
A population of 116,090 asymptomatic women between the ages of 20 and 40 was examined for the cytologic presence of dysplasia and koilocytosis presumably resulting from condyloma acuminata of the uterine cervix. Subpopulations of 50 women with severe dysplasia and 50 with severe dysplasia and koilocytosis (= condyloma) were selected for a short-term study of progression to carcinoma or carcinoma in situ. The cytologic preparations examined by morphometry to determine the quantitative morphologic characteristics of the epithelial populations in the two groups showed that patients with condyloma and dysplasia had a different population of cells than those with dysplasia alone. Histologic studies showed that there were significantly more mitotic abnormalities in the condylomatous lesions, consistent with viral alterations of mitosis. While short-term follow-up (three to four years) failed to show that patients with both dysplasia and condyloma were at higher risk of developing cancer than patients with dysplasia alone, patients with condyloma of the cervix should be closely followed clinically since they have a higher risk of other cervical abnormalities.
对116,090名年龄在20至40岁之间的无症状女性进行了检查，以确定是否存在可能由子宫颈尖锐湿疣引起的发育异常和凹空细胞的细胞学表现。从这些女性中挑选出50名患有严重发育异常的女性和50名患有严重发育异常且伴有凹空细胞（即尖锐湿疣）的女性，进行短期研究，观察其进展为癌或原位癌的情况。通过形态计量学检查细胞学标本，以确定两组上皮细胞群体的定量形态学特征，结果显示，患有尖锐湿疣和发育异常的患者与仅患有发育异常的患者的细胞群体不同。组织学研究表明，尖锐湿疣病变中的有丝分裂异常明显更多，这与有丝分裂的病毒改变一致。虽然短期随访（三至四年）未能表明同时患有发育异常和尖锐湿疣的患者比仅患有发育异常的患者患癌风险更高，但宫颈尖锐湿疣患者应接受密切的临床随访，因为她们患其他宫颈异常的风险更高。
