Verp M S, Rzeszotarski M S, Martin A O, Simpson J L
Am J Obstet Gynecol. 1983 Feb 15;145(4):433-8. doi: 10.1016/0002-9378(83)90313-7.
The hypothesis that variation in Y-chromosome length is associated with repetitive fetal wastage was tested. Chromosome lengths were objectively quantitated by scanning photographic negatives of metaphases with a computer programmed to (1) select boundary thresholds and (2) construct and measure centerlines with a cubic spline-fitting algorithm. Variation in Y length among cells of different individuals was standardized by use of the ratio of the length of the Y to the average of the lengths of the No. 20s (20) in the same cell. Three groups were studied: (1) men whose wives had three or more spontaneous abortions and no live-born infants, (2) men whose wives had both abortions and normal live-born infants, and (3) control men whose wives had normal live-born infants only. Although central tendencies were similar in the three groups, the distributions of Y lengths among the three groups were significantly different (chi 2(6) = 15.33, 0.025 greater than p greater than 0.010). This difference was primarily because more of the subjects with only repetitive loss had Y lengths in the "tails" of the distribution rather than in the center. Our observations suggest the existence of an optimal Y length with respect to reproductive performance.
对Y染色体长度变异与反复胎儿丢失相关的假说进行了检验。通过用计算机扫描中期相的照相底片来客观定量染色体长度，该计算机程序被设定为：(1)选择边界阈值；(2)用三次样条拟合算法构建并测量中心线。通过使用同一细胞中Y染色体长度与第20号染色体（20）长度平均值的比值，对不同个体细胞间的Y染色体长度变异进行标准化。研究了三组对象：(1)妻子有三次或更多次自然流产且无存活婴儿的男性；(2)妻子既有流产又有正常存活婴儿的男性；(3)妻子仅有正常存活婴儿的对照男性。尽管三组的集中趋势相似，但三组间Y染色体长度的分布有显著差异（卡方(6)=15.33，0.025＞p＞0.010）。这种差异主要是因为更多仅有反复流产的受试者其Y染色体长度处于分布的“尾部”而非中心。我们的观察结果提示，在生殖性能方面存在一个最佳的Y染色体长度。
