Morgan A, Holmes A
Br J Ind Med. 1983 Feb;40(1):45-50. doi: 10.1136/oem.40.1.45.
Concentrations of uncoated and coated amphibole fibres were measured postmortem in samples taken from the periphery of both upper and lower lobes of the left lung of an insulation worker. Similar measurements were made on a more limited range of samples from elsewhere in the lung and on a hilar lymph node. The mean concentration of uncoated fibres in the upper lobe was twice that in the lower. Significant differences were observed in the mean concentration of uncoated fibres in different regions of the periphery, the diaphragmatic region having the lowest value. Variations in the concentrations of both uncoated and coated fibres in the costal region of the lower lobe may have been related to the effect of rib structures on ventilation. Concentrations of fibrous and non-fibrous dust were well correlated in the peripheral samples. The length distributions of uncoated and coated fibres were also measured and differences detected in fibres from the various regions of the lung. This work emphasises the care required in sampling lung tissue in order to obtain representative material for the determination of fibre concentration.
对一名绝缘工人左肺上叶和下叶周边采集的样本进行了尸检，测量了未包覆和包覆角闪石纤维的浓度。对来自肺部其他部位范围更有限的样本以及一个肺门淋巴结也进行了类似测量。上叶中未包覆纤维的平均浓度是下叶的两倍。在周边不同区域未包覆纤维的平均浓度存在显著差异，膈区的值最低。下叶肋区未包覆和包覆纤维浓度的变化可能与肋骨结构对通气的影响有关。周边样本中纤维性和非纤维性粉尘的浓度高度相关。还测量了未包覆和包覆纤维的长度分布，并检测到来自肺不同区域纤维的差异。这项工作强调了在采集肺组织样本时需要谨慎，以便获得用于测定纤维浓度的代表性材料。
