Morgan A, Holmes A
Br J Ind Med. 1980 Feb;37(1):25-32. doi: 10.1136/oem.37.1.25.
Concentrations and length distributions of uncoated and coated amphibole-type fibres in samples of human lung taken at necropsy were measured by optical microscopy using the membrane filter technique that enables fibres with diameters down to about 0.2 micron to be detected. The subjects included 10 who died with mesothelial tumours, three with lung cancer, and eight of other causes. Measurements of fibre concentrations are compared with those of other workers. It can be deduced from the length distributions that fibres less than 5 microns long are cleared from the lung more efficiently than longer ones. The clearance of short fibres appears to be inhibited in subjects with asbestosis, however. The length distributions of uncoated and coated fibres were dissimilar. In general, few fibres less than 10 microns in length were coated and few greater than 40 microns in length were uncoated. The probability of a fibre of given length, however, becoming coated varied considerably from subject to subject. Possible reasons for this are discussed.
采用膜滤技术，通过光学显微镜测量了尸检时采集的人肺样本中未涂层和涂层闪石型纤维的浓度及长度分布，该技术能够检测直径低至约0.2微米的纤维。受试者包括10名死于间皮瘤的人、3名死于肺癌的人以及8名因其他原因死亡的人。将纤维浓度的测量结果与其他研究人员的结果进行了比较。从长度分布可以推断，长度小于5微米的纤维比更长的纤维从肺中清除得更有效。然而，在患有石棉沉着病的受试者中，短纤维的清除似乎受到抑制。未涂层和涂层纤维的长度分布不同。一般来说，长度小于10微米的纤维很少有涂层，长度大于40微米的纤维很少没有涂层。然而，给定长度的纤维被涂层的概率因受试者而异。文中讨论了可能的原因。
